Cyclobenzaprine Usage and Precautions

Introduction to Cyclobenzaprine

• Cyclobenzaprine is structurally related to tricyclic antidepressants and has anticholinergic effects 1

Special Considerations for Patient Populations

• Cyclobenzaprine appears on the American Geriatrics Society Beers Criteria as potentially inappropriate for older adults due to anticholinergic effects 2

Precautions and Contraindications

• Long-term use can lead to dependence and withdrawal symptoms; tapering over 2-3 weeks is recommended when discontinuing after extended use 1
• Concomitant use with monoamine oxidase inhibitors may increase the risk of serotonin syndrome 1