Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 10/7/2025

Keloid Formation and Risk Factors

Triggering Injuries and Risk Factors

  • Body piercings, such as ear, nose, nipples, and navel piercings, can trigger keloid formation, with an occurrence rate of approximately 2.5% in ear piercings and a higher infection rate of 18.4% in professional shops, which can lead to keloid formation, as reported by the American Academy of Pediatrics 1, 2

Genetic Predisposition

  • There is a strong genetic component to keloid formation, with predisposition being genetically transmitted, and patients with a personal or family history of keloids face a significantly elevated risk with any skin trauma, according to the National Institute of Environmental Health Sciences 4, 5