Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/10/2025

Management of Vaginal Bleeding Due to Oral Contraceptive Use

Safety Considerations and Contraindications

  • The Centers for Disease Control and Prevention recommends that tranexamic acid is contraindicated in women with active thromboembolic disease, history or intrinsic risk for thrombosis or thromboembolism 1

Important Clinical Considerations

  • The Centers for Disease Control and Prevention suggests that tranexamic acid may be considered as a first-line treatment for idiopathic menorrhagia, especially for patients in whom hormonal treatment is either not recommended or not wanted, and has shown superior efficacy compared to NSAIDs for patients with heavy bleeding due to intrauterine devices 1