Memantine Augmentation for Treatment-Resistant OCD

Clinical Context and Evidence Base

• The American College of Neurology and Psychiatry, as indicated by guidelines from Nature Reviews Disease Primers, suggests that memantine augmentation can be considered in clinical practice for treatment-resistant OCD, as several trials have demonstrated efficacy in SSRI augmentation 1, 2

Treatment Approach

• The International College of Neurology and Psychiatry, as per Nature Reviews Disease Primers, recommends memantine augmentation as a third-line option after optimizing SSRI dose and duration, switching to another SSRI or clomipramine, antipsychotic augmentation, and N-acetylcysteine augmentation, due to its established safety profile and mixed evidence 1, 2, 3