Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 10/26/2025

Management of Comorbid Anxiety with Lurasidone

First-Line Treatment for Primary Anxiety Disorders

  • The American Academy of Child and Adolescent Psychiatry recommends SSRIs, particularly escitalopram or sertraline, as first-line pharmacotherapy for anxiety disorders 1
  • Buspirone is an alternative for mild-to-moderate generalized anxiety when SSRIs are contraindicated or not tolerated, as suggested by the Praxis Medical Insights 2

Acute Anxiety Management

  • The BMJ recommends benzodiazepines, such as lorazepam or midazolam, for acute anxiety management, although they carry a dependence risk 3, 4