Plasmapheresis in Rodenticide Poisoning

Risks and Limitations of Plasmapheresis

Mortality associated with plasmapheresis is estimated at 0.05% based on systematic reviews 1
Plasmapheresis might be considered in poisonings where the toxic substance has high plasma protein binding 1
Potential complications of plasmapheresis include hemodynamic shifts 2
Potential complications of plasmapheresis include increased infection risk 1
Potential complications of plasmapheresis include thrombosis 1
Potential complications of plasmapheresis include removal of important plasma proteins including clotting factors 1

For water-soluble toxins with low protein binding, hemodialysis may be preferred over plasmapheresis 2

If plasmapheresis is attempted, human albumin or fresh frozen plasma should be used as replacement fluids 1