Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/16/2025

Treatment of Streptococcal Conjunctivitis

Diagnosis and Initial Assessment

  • Streptococcal conjunctivitis typically presents with marked inflammation, purulent discharge, and sometimes pain in patients with conjunctivitis, according to the American Academy of Ophthalmology 1
  • Consider obtaining conjunctival cultures and Gram staining before initiating treatment, especially in moderate to severe cases of conjunctivitis, as recommended by the American Academy of Ophthalmology 1
  • Examine for swollen preauricular or submandibular lymph nodes, which may indicate bacterial infection in patients with conjunctivitis, as suggested by the American Academy of Ophthalmology 3

Treatment Recommendations

  • Broad-spectrum topical antibiotics for 5-7 days with application 4 times daily are recommended as first-line treatment for streptococcal conjunctivitis, according to the American Academy of Ophthalmology 1, 2
  • Fluoroquinolones, such as moxifloxacin and gatifloxacin, are effective against common pathogens including Streptococcus species in patients with conjunctivitis, as recommended by the American Academy of Ophthalmology 1
  • Aminoglycosides like tobramycin are also effective options for treating streptococcal conjunctivitis, according to the American Academy of Ophthalmology 1

Special Considerations

  • Patients should be advised to return for follow-up if no improvement is seen after 3-4 days of treatment for conjunctivitis, as recommended by the American Academy of Ophthalmology 1, 2
  • Avoid using topical corticosteroids unless under close supervision, as they may prolong bacterial shedding and worsen infection in patients with conjunctivitis, according to the American Academy of Ophthalmology 3
  • For severe inflammation with marked chemosis or eyelid swelling, topical corticosteroids may be considered but require close follow-up, as suggested by the American Academy of Ophthalmology 3

Patient Education

  • Bacterial conjunctivitis is highly contagious; advise patients about hygiene measures to prevent spread, such as frequent hand washing and avoiding sharing of personal items, as recommended by the American Academy of Ophthalmology 3
  • Instruct patients to avoid sharing towels, pillowcases, and makeup to prevent the spread of conjunctivitis, according to the American Academy of Ophthalmology 1
  • Patients should wash hands frequently and avoid touching their eyes to prevent the spread of conjunctivitis, as recommended by the American Academy of Ophthalmology 1

Follow-Up Recommendations

  • Schedule follow-up within 1 week for severe cases with corneal involvement or membranous conjunctivitis, as recommended by the American Academy of Ophthalmology 3, 4
  • For mild cases, instruct patients to return if symptoms persist beyond 2-3 weeks, according to the American Academy of Ophthalmology 3
  • Follow-up should include interval history, visual acuity measurement, and slit-lamp biomicroscopy to monitor the progression of conjunctivitis, as suggested by the American Academy of Ophthalmology 4

REFERENCES

1

Treatment of Bacterial Conjunctivitis [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

3

Treatment of Bacterial Conjunctivitis: Frequency and Duration [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025