Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/5/2025

COVID-19 Booster Recommendations

Current Booster Recommendations by Age Group

  • The Centers for Disease Control and Prevention recommends that all persons aged ≥5 years should receive a bivalent mRNA COVID-19 vaccine booster dose at least 2 months after completing their primary series or after receiving a monovalent booster dose to improve protection against COVID-19, particularly for those at increased risk for severe illness and death 1, 2
  • Children aged 5 years should receive a Pfizer-BioNTech bivalent booster ≥2 months after primary series or monovalent booster 3
  • Children aged 6-11 years should receive either Moderna or Pfizer-BioNTech bivalent booster ≥2 months after primary series or monovalent booster 1
  • Adolescents aged 12-17 years should receive either Moderna or Pfizer-BioNTech bivalent booster ≥2 months after primary series or monovalent booster 4
  • Adults aged ≥18 years should receive either Moderna or Pfizer-BioNTech bivalent booster ≥2 months after primary series or monovalent booster 1
  • For adults who cannot or will not receive mRNA vaccines, the Novavax monovalent booster may be used if they completed any FDA-approved or FDA-authorized primary series, have not received any booster doses, and are unable or unwilling to receive an mRNA vaccine 4

Special Considerations

  • Immunocompromised individuals may benefit from additional protection with Evusheld (tixagevimab and cilgavimab) administered every 6 months to supplement vaccine-conferred protection 5

Timing Considerations

  • Persons who recently had a SARS-CoV-2 infection may consider delaying a booster dose by 3 months from symptom onset or positive test result (if asymptomatic) 1, 4
  • Bivalent booster doses are authorized ≥2 months after the last primary series or monovalent booster dose 3
  • The Novavax monovalent booster is authorized ≥6 months after the last primary series dose 4

Rationale for Bivalent Boosters

  • Monovalent COVID-19 vaccines demonstrated decreased effectiveness during the Omicron variant predominance period 6
  • Bivalent boosters contain equal amounts of spike mRNA from both the ancestral strain and Omicron BA.4/BA.5 strains to improve protection against current circulating variants 7

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