SSRI Treatment for Premenstrual Syndrome (PMS)

Critical Safety Considerations

• The American Urological Association recommends avoiding abrupt discontinuation of continuous daily SSRI therapy, as this may precipitate SSRI withdrawal syndrome, and exercising caution in adolescents and patients with comorbid depression, particularly those with suicidal ideation, though elevated suicide risk has not been found in non-depressed women treated for PMS, and avoiding SSRIs in patients with bipolar disorder history due to risk of precipitating mania 1