Hookworm Infection Management

Treatment Regimens

The American College of Cardiology is not applicable here, however, the standard treatment for hookworm infection is albendazole 400 mg orally as a single dose, repeated in 2 weeks, which is effective against both Ancylostoma duodenale and Necator americanus 1
Alternative treatment options include mebendazole 500 mg as a single oral dose, mebendazole 100 mg twice daily for 3 days, or ivermectin 200 μg/kg as a single dose, particularly when benzimidazoles are not available 2

For patients with prolonged exposure in endemic areas and negative stool tests, treat empirically with albendazole 400 mg plus ivermectin 200 μg/kg as a single dose, due to the high false-negative rates of standard stool microscopy and the increased exposure risk despite negative testing 1
In areas with documented mebendazole resistance, use ivermectin 200 μg/kg as a single dose 2

Implement hand hygiene and wearing shoes in endemic areas to prevent reinfection, and screen and treat household contacts in endemic settings 1, 2
Address iron-deficiency anemia with iron supplementation in patients with heavy infections, as hookworm causes blood loss through intestinal attachment 2

For cutaneous larva migrans caused by Ancylostoma braziliense or A. caninum, treatment options include ivermectin 200 μg/kg single dose orally, or albendazole 400 mg once daily for 3 days 3