Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/19/2025

Udenafil Dosage and Usage for Erectile Dysfunction

Dosing Recommendations

  • Dose titration is important to provide optimal efficacy, as recommended for all PDE5 inhibitors 1

Special Populations

  • Similar to other PDE5 inhibitors, caution should be exercised in patients with hepatic or renal impairment, with potential need for lower doses 1
  • In men with diabetes or post-prostatectomy, response may be less robust, as observed with other PDE5 inhibitors 1

Safety and Adverse Events

  • Like other PDE5 inhibitors, udenafil is contraindicated in patients taking nitrates due to risk of significant hypotension 1

Important Instructions for Patients

  • Sexual stimulation is necessary for udenafil to be effective, as with all PDE5 inhibitors 1
  • Incorrect use (lack of sexual stimulation, medication taken with a large meal) accounts for many treatment failures 1
  • Multiple trials with the medication may be required to establish efficacy 1

REFERENCES

1

erectile dysfunction: aua guideline. [LINK]

The Journal of urology, 2018