Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/23/2025

Oxycodone HCL IR Dosing for Moderate to Severe Pain

Dosing Considerations

  • For breakthrough pain, a "breakthrough dose" is typically equivalent to 10% of the total daily dose, and if more than 4 breakthrough doses per day are necessary, the baseline opioid treatment should be adjusted 1

Comparative Efficacy

  • Oxycodone is approximately 1.5-2 times as potent as oral morphine 2