Systemic Lupus Erythematosus Diagnosis and Presentation

Constitutional and Mucocutaneous Symptoms

• Fever may occur during initial disease activity and must be distinguished from infection, according to the American College of Rheumatology, in patients with Systemic Lupus Erythematosus 1

Renal and Neuropsychiatric Involvement

• Renal involvement may present with proteinuria or hematuria early in disease, as noted by the European League Against Rheumatism, in patients with Systemic Lupus Erythematosus 1
• Neuropsychiatric symptoms, including headache, mood disorders, or seizures, can occur at onset, as reported by the American College of Rheumatology, in approximately 50-60% of patients within the first year of disease 2, 3

Hematologic Abnormalities

• Hematologic abnormalities, such as thrombocytopenia, leukopenia, or lymphopenia, may be detected in patients with Systemic Lupus Erythematosus, according to the European League Against Rheumatism 1