Management and Follow‑up Recommendations for Epididymo‑orchitis

Diagnostic Testing

• The CDC (MMWR Recommendations and Reports) advises that, at the time of clinical diagnosis, nucleic acid amplification tests (NAATs) should be obtained for Neisseria gonorrhoeae and Chlamydia trachomatis to confirm infection. 1, 2

Patient Counseling and Partner Management

• The CDC recommends sexual abstinence for at least 7 days after a single‑dose ceftriaxone regimen—or until the full course of multi‑day antibiotics is finished and symptoms have resolved—to prevent transmission. 1
• The CDC mandates that all sexual partners from the preceding 60 days be notified, evaluated, and treated empirically for gonorrhea and chlamydia, regardless of test results. 1
• The CDC advises that patients be screened for additional sexually transmitted infections, including syphilis and HIV, at the initial visit. 1

Follow‑up and Reinfection Prevention

• The CDC recommends repeat testing for gonorrhea and chlamydia 3–6 months after treatment because reinfection rates in this population are high. 1