Clindamycin Dosage Guidelines

Introduction to Clindamycin Dosage

• For pediatric patients, the recommended clindamycin dosage is 30-40 mg/kg/day divided into 3-4 doses for oral therapy and 40 mg/kg/day divided into 3-4 doses for parenteral therapy, while adults should receive 150-450 mg every 6 hours orally or 600-2700 mg/day parenterally depending on infection severity 1

Dosage by Infection Type

• For MRSA infections (susceptible to clindamycin): 30-40 mg/kg/day in 3-4 doses 1, 2
• For Group A Streptococcus: 40 mg/kg/day in 3 doses 1, 2
• For methicillin-susceptible S. aureus: 30-40 mg/kg/day in 3-4 doses 1, 2
• For S. pneumoniae: 40 mg/kg/day every 6-8 hours 1, 2
• For Group A Streptococcus: 40 mg/kg/day every 6-8 hours 1, 2
• For MRSA (susceptible to clindamycin): 40 mg/kg/day every 6-8 hours 1, 2

Treatment Duration and Recommendations

• For serious infections, particularly those caused by MRSA, the higher dosing regimen (40 mg/kg/day) is recommended by current guidelines 1, 2

Important Considerations

• Dosing typically ranges from 600-2700 mg/day divided into 2-4 doses, based on infection severity 1, 2
• When transitioning from IV to oral therapy, ensure adequate dosing is maintained to prevent treatment failure, particularly for serious infections like osteomyelitis or MRSA infections 1, 2