Role of CYP3A4 in Prednisone Metabolism

Monitoring Considerations

• Patients taking medications that affect CYP3A4 activity, such as transplant recipients on prednisone and calcineurin inhibitors, should be monitored for altered prednisone efficacy or toxicity, as recommended by the American Society of Transplantation 1, 2, 3
• When prescribing new medications to patients on prednisone, it's imperative to review for possible drug interactions with the CYP3A4 pathway, according to the American College of Chest Physicians 4, 5