Pharmacokinetics and Dosing of Brivaracetam in Renal Impairment

Comparison with Other Antiepileptic Medications

• Medications like pyrazinamide are dialyzed to a significant degree and require post-dialysis dosing, in contrast to brivaracetam which has minimal dialytic clearance 1
• For medications that are significantly removed by dialysis, administration after hemodialysis is generally recommended to avoid drug loss and maintain therapeutic levels, as suggested by the American Thoracic Society 1, 2