Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/18/2025

Reducing Risk of Fat Embolism During Interlocking Nail Femur Surgery

Pathophysiology and Risk

  • Early surgical stabilization of femoral shaft fractures within 24 hours of injury is strongly recommended to prevent fat embolism syndrome and ARDS, according to the American Society of Anesthesiologists 1
  • Fat embolism syndrome can occur during procedures that breach the femoral canal, such as intramedullary nailing, and is a concern in patients undergoing femur surgery 2

Surgical Techniques to Reduce Fat Embolism Risk

  • Thoroughly washing and drying the femoral canal before cement or prosthesis insertion can help reduce the risk of fat embolism, as recommended by the American Academy of Orthopaedic Surgeons 3, 4
  • Using a pressurized lavage system to clean endosteal bone of fat and marrow contents can help reduce the risk of fat embolism 3, 2
  • Avoiding excessive manual pressurization in high-risk patients can help reduce the risk of fat embolism, according to the American Heart Association 3
  • Inserting cement from a gun in retrograde fashion on top of the plug can help reduce the risk of fat embolism 4
  • Pulling the suction catheter out as soon as it is blocked with cement can help reduce the risk of fat embolism 3
  • Avoiding vigorous pressurization of cement in patients at risk of cardiovascular compromise can help reduce the risk of fat embolism 4

Anesthetic Considerations

  • Ensuring adequate hydration before induction of and during anesthesia can help reduce the risk of fat embolism, as recommended by the American Society of Anesthesiologists 3
  • Maintaining systolic blood pressure within 20% of pre-induction values throughout surgery can help reduce the risk of fat embolism 3, 4
  • Increasing inspired oxygen concentration during critical moments of the procedure can help reduce the risk of fat embolism 5

Post-operative Considerations

  • Administering supplemental oxygen for at least 24 hours postoperatively can help reduce the risk of fat embolism, according to the American Thoracic Society 5

Important Caveats

  • Corticosteroids are not recommended for prevention of fat embolism syndrome, as stated by the American College of Surgeons 6
  • Early stabilization (within 24 hours) is associated with lower risk of fat embolism, according to the American Academy of Orthopaedic Surgeons 1