Cefuroxime Use in Pregnancy

Safety Profile

• Cefuroxime is classified as FDA Pregnancy Category B1, indicating compatibility during pregnancy, according to the European Respiratory Society guidelines 1, 2
• The European Respiratory Society/Thoracic Society of Australia and New Zealand guidelines state that human data demonstrate cefuroxime and other cephalosporins are not teratogenic at usual therapeutic doses 1, 2

Clinical Applications During Pregnancy

• Cefuroxime is recommended as a first-line option for respiratory tract infections in pregnancy, explicitly listed as compatible throughout all trimesters 1, 2
• The French guidelines recommend cefuroxime for surgical prophylaxis in cardiac, vascular, and orthopedic procedures during pregnancy 3

Breastfeeding

• Cefuroxime is compatible with breastfeeding, according to the European Respiratory Society guidelines, although caution should be exercised as with any medication during lactation 1, 2

General Considerations

• All cephalosporins, including cefuroxime, are considered low-risk options during pregnancy, making them part of a broader safe antibiotic category, as stated by the European Respiratory Society 4