Dosing of Amoxicillin-Clavulanate in Renal Impairment

Monitoring and Treatment Recommendations

• The Infectious Diseases Society of America recommends assessing renal function before initiating therapy and periodically during treatment, and for patients with fluctuating renal function, reassess GFR every 2-3 days to adjust dosing as needed 1
• The Infectious Diseases Society of America suggests paying special attention to elderly patients who often have decreased renal function even with normal serum creatinine levels, and considering consulting with infectious disease specialists and clinical pharmacists for optimal antimicrobial selection in patients with severe infections and significant renal impairment 1
• The American Thoracic Society recommends considering respiratory fluoroquinolones (with appropriate renal dose adjustments) as alternative agents when treating respiratory infections in patients with renal impairment 2