Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 6/12/2025

Vitamin D Supplementation and Kidney Stone Prevention

Introduction to Vitamin D and Kidney Stones

  • The U.S. Preventive Services Task Force (USPSTF) found adequate evidence that supplementation with vitamin D and calcium increases the incidence of renal stones 1
  • Vitamin D supplementation does not help prevent kidney stones and may actually increase the risk of stone formation, particularly when combined with calcium supplements 1

Prevention Strategies

  • Increase fluid intake to produce at least 2 liters of urine per day, as recommended by the American Urological Association 2
  • Maintain a normal body mass index, as suggested by the National Kidney Foundation 2
  • Be cautious with vitamin C supplements as doses ≥1000 mg/day may increase stone risk by 40% due to increased oxalate excretion, according to the American Urological Association 2

Dietary Recommendations

  • Maintain adequate dietary calcium rather than taking supplements, as dietary calcium has a protective effect against kidney stones by reducing intestinal oxalate availability and reducing urinary oxalate excretion 1
  • Increase intake of vegetables and fibers, although the specific guideline society is not mentioned in the article, it is a generally recommended practice for overall health 2

Supplementation Guidance

  • Avoid vitamin D supplements if you have a history of kidney stones or are at high risk, as recommended by the U.S. Preventive Services Task Force (USPSTF) 1