Complications After RSV and Flu Vaccines

Common Local Reactions

Pain at the injection site occurs in 10-64% of patients after influenza vaccination and typically resolves within 2 days, according to the Centers for Disease Control and Prevention (CDC) 1
Administer vaccines in different limbs when giving multiple vaccines that may cause injection site reactions, as recommended by the CDC 2

Fever begins 6-12 hours post-vaccination and persists 1-2 days, with age-specific fever rates after influenza vaccine: 11.5% (ages 1-5 years), 4.6% (ages 6-10 years), 5.1% (ages 11-15 years), as reported by the CDC 1
High-risk children aged 6 months-4 years may experience fever rates up to 27%, according to the CDC 1
Malaise and myalgia typically resolve within 1-2 days, as stated by the American Academy of Pediatrics 4

Immediate allergic reactions (hives, angioedema, allergic asthma, anaphylaxis) rarely occur and likely result from residual egg protein in influenza vaccines, according to the CDC 1
Persons with documented IgE-mediated hypersensitivity or history of anaphylaxis to eggs should NOT receive influenza vaccine, as recommended by the CDC 1
The 1976 swine influenza vaccine was associated with <10 cases per 1 million vaccinated of Guillain-Barré Syndrome (GBS), as reported by the CDC 1

Nirsevimab is contraindicated in persons with history of severe allergic reaction (anaphylaxis) after previous dose or to product component, according to the Advisory Committee on Immunization Practices (ACIP) 6
For children with increased bleeding risk, follow ACIP general best practice guidelines for immunization, as recommended by the ACIP 6

Report ALL clinically significant adverse events to VAERS, even without certainty of causation, as required by the CDC and the Food and Drug Administration (FDA) 1, 3
Any adverse event resulting in hospitalization, disability, or death requires VAERS reporting, according to the CDC and the FDA 3
For nirsevimab adverse reactions with coadministered vaccines, report to VAERS only (not MedWatch separately), as instructed by the CDC and the FDA 6