Safe Combination of Levetiracetam and Clonazepam for Seizure Management

Clinical Considerations

• The American Geriatrics Society recommends monitoring for excessive sedation, drowsiness, or respiratory depression when using levetiracetam and clonazepam together, due to their additive central nervous system effects 1
• Clinicians should be prepared to provide respiratory support and monitor oxygen saturation continuously when using these medications together, particularly in acute settings, as recommended by clinical guidelines 2