Fosphenytoin Compatibility and Administration

Introduction to Fosphenytoin

• The American College of Medical Toxicology and other medical societies note that fosphenytoin has superior water solubility, allowing compatibility with dextrose solutions, unlike phenytoin, which must be diluted only in normal saline due to precipitation with glucose-containing solutions 1

Pharmaceutical Characteristics

• Fosphenytoin's formulation does not contain propylene glycol or ethanol, which are present in phenytoin preparations, contributing to its improved solubility 2