Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 10/14/2025

ECG Parameters to Assess Before Lacosamide Administration

Essential Pre-Treatment ECG Parameters

  • Obtain thorough cardiac history including syncope, near-syncope, chest pain, palpitations, and known heart disease, as recommended by the American Heart Association, in patients prior to lacosamide administration 1
  • History of structural heart disease increases risk of conduction disturbances, according to the American College of Cardiology 2

High-Risk Patient Populations Requiring Mandatory ECG

  • Patients on drugs known to prolong PR interval, such as beta-blockers, calcium channel blockers, and digoxin, need baseline assessment, as suggested by the American Heart Association 3
  • Baseline ECG is recommended for patients on any cardiovascular medications, as stated by the American College of Cardiology 2