Calcium Channel Blockers

Mechanism of Action and Effects

• Amlodipine, as a dihydropyridine calcium channel blocker, has more pronounced peripheral vasodilatory effects compared to non-dihydropyridines like verapamil and diltiazem, with minimal cardiac effects on atrioventricular conduction and heart rate, according to the American College of Cardiology 1
• The most common side effect of amlodipine is peripheral edema, related to its vasodilatory action, causing preferential dilation of arterioles over venules, as noted in clinical guidelines 2