Piperacillin-Tazobactam Dosing Guidelines

Introduction to Dosing Considerations

• The American Academy of Pediatrics and other guideline societies recommend weight-based dosing for pediatric patients, with dosing adjustments for patients weighing up to 40 kg 1

Pediatric Weight-Based Dosing

• For children weighing up to 40 kg, the FDA recommends 90 mg/kg (piperacillin component) every 8 hours for appendicitis/peritonitis and every 6 hours for nosocomial pneumonia, according to the Journal of Microbiology, Immunology and Infection 1
• The Infectious Diseases Society of America suggests that pediatric patients weighing over 40 kg should receive adult dosing, but at exactly 40 kg, weight-based pediatric dosing provides more precision 2

Adult Standard Dosing

• The American College of Clinical Pharmacy recommends standard infections be treated with 3.375 g every 6 hours, according to Praxis Medical Insights 2

Renal Impairment

• The National Kidney Foundation recommends dose reduction for patients with renal impairment, with CrCl 20-40 mL/min requiring 2.25 g every 6 hours and CrCl <20 mL/min requiring 2.25 g every 8 hours, as stated in Praxis Medical Insights 2