Desvenlafaxine Dosing and Discontinuation for Major Depressive Disorder

Discontinuation Protocol

• Tapering desvenlafaxine over 10-14 days is recommended to limit withdrawal symptoms, as suggested by the American family physician 1
• A gradual dose reduction is advised when discontinuing treatment, with the 25 mg per day dose intended for this purpose, according to guidelines from the American family physician and other sources 1, 2