Gradual Tapering of Mirtazapine

General Guidelines

• The American Family Physician recommends discontinuing antidepressants over 10 to 14 days to limit withdrawal symptoms 1

Recommended Tapering Schedule

• A gradual tapering schedule is recommended, starting with a 10-20% reduction of the current dose, maintaining each reduced dose for 1-2 weeks before making further reductions 2
• As the dose decreases to approximately 25% of the original dose, slow the taper to 5-10% reductions to minimize withdrawal effects 2

Special Considerations

• Elderly patients require even more gradual tapering due to increased sensitivity to medication effects and withdrawal symptoms 2

Supportive Measures During Tapering

• Non-pharmacological interventions, including cognitive-behavioral therapy, sleep hygiene education, and anxiety management techniques, can support the tapering process 2
• Clear patient education about the expected timeline and possible withdrawal symptoms can improve adherence to the tapering schedule 2
• Regular follow-up appointments can assess progress and adjust the tapering schedule as needed based on individual tolerance 2