Cefdinir for Treatment of Cellulitis

Efficacy and Guidelines

Cellulitis is primarily caused by streptococci, particularly group A streptococcus, though Staphylococcus aureus may also be involved in certain cases 1, 2
According to the Infectious Diseases Society of America (IDSA) guidelines, first-line therapy for typical cellulitis should include antibiotics active against streptococci 1, 3
Recommended first-line oral antibiotics for typical cellulitis include penicillin, amoxicillin, amoxicillin-clavulanate, dicloxacillin, cephalexin, or clindamycin 2

MRSA is an unusual cause of typical cellulitis according to IDSA guidelines 4
MRSA coverage may be prudent in cellulitis associated with penetrating trauma, purulent drainage, or concurrent evidence of MRSA infection elsewhere 3, 4
For uncomplicated cellulitis, a 5-day course of antimicrobial therapy is as effective as a 10-day course if clinical improvement has occurred by day 5 1, 2

Consider alternative antibiotics if there is evidence of MRSA infection 4
Consider alternative antibiotics if the patient has severe infection requiring intravenous therapy 1
Consider alternative antibiotics if the patient has significant comorbidities like diabetes or immunosuppression 4
Adjunctive measures should include elevation of the affected area to promote drainage of edema 2
Adjunctive measures should include treatment of any predisposing conditions such as tinea pedis, trauma, or venous eczema 2