Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 2/10/2026

Maximum Safe Dose and Indication‑Specific Dosing of Ursodeoxycholic Acid (UDCA)

General Safety Limits

Primary Biliary Cholangitis (PBC)

Primary Sclerosing Cholangitis (PSC)

Pregnancy (PBC, PSC, Intra‑hepatic Cholestasis of Pregnancy)

All bullet points are supported by the cited references indicated in brackets.

Ursodiol Dosing Guidelines for Primary Biliary Cholangitis and Primary Sclerosing Cholangitis

Primary Biliary Cholangitis (PBC)

Primary Sclerosing Cholangitis (PSC)