Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/23/2025

Difficult Airway Management

Definition and Classification

  • A difficult airway is defined as a clinical situation in which a physician trained in anesthesia care experiences anticipated or unanticipated difficulty or failure with face-mask ventilation, laryngoscopy, ventilation using a supraglottic airway, tracheal intubation, extubation, or invasive airway, according to the American Society of Anesthesiologists (ASA) 1
  • Difficult laryngoscopy is defined as inability to visualize any portion of the vocal cords after multiple attempts at laryngoscopy, as stated by the ASA 1, 3
  • The Cormack & Lehane classification is used to grade difficult laryngoscopy, with grade 3 being subdivided into 3a (epiglottis can be lifted) and 3b (epiglottis cannot be lifted from the posterior pharyngeal wall), as described by the Anaesthesia society 4

Signs of Inadequate Ventilation

  • Absent or inadequate exhaled carbon dioxide is a sign of inadequate ventilation, as indicated by the ASA 2
  • Absent or inadequate chest movement is a sign of inadequate ventilation, as indicated by the ASA 2
  • Decreasing or inadequate oxygen saturation is a sign of inadequate ventilation, as indicated by the ASA 2
  • Changed mental status or somnolence can be a sign of inadequate ventilation, as stated by the ASA 1, 3

Clinical Application

  • The definitions of difficult airway apply to all airway management and anesthetic care delivered in ambulatory settings, such as surgery centers and office-based procedures, as stated by the ASA 5, 7
  • The guidelines are intended for use by anesthesiologists and all others who perform anesthesia care or airway management, as stated by the ASA 7

Management Approach

  • Management of difficult airways should follow a structured algorithm with Plans A through D, as outlined by airway management societies, including the Anaesthesia society 4, 8, 9
  • Each plan should be implemented sequentially based on the outcome of the previous plan, as described by the Anaesthesia society 4