Unasyn Dosing Guidelines for Specific Infections

Endocarditis Treatment

The American Heart Association recommends 12 g/day IV in 4 equally divided doses (3 g every 6 hours) for adults with endocarditis, which aligns with the upper end of FDA dosing 1
For pediatric endocarditis, the American Heart Association recommends 300 mg/kg/day IV in 4-6 equally divided doses 1, 2
For HACEK endocarditis (native or prosthetic valve), the recommended dose is 12 g/24 hours IV in 4 equally divided doses (3 g every 6 hours) for 4 weeks (native valve) or 6 weeks (prosthetic valve) in adults 2
For HACEK endocarditis (native or prosthetic valve), the recommended dose is 300 mg/kg/24 hours IV divided into 4 or 6 equally divided doses in pediatric patients 2
For culture-negative endocarditis (native valve), the recommended dose is 12 g/day IV in 4 equally divided doses for 4-6 weeks, combined with gentamicin in adults 1
For culture-negative endocarditis (native valve), the recommended dose is 300 mg/kg/day IV in 4-6 equally divided doses for 4-6 weeks in pediatric patients 1

For complicated pediatric intra-abdominal infections, 200 mg/kg/day of ampicillin-sulbactam given every 6 hours is recommended 3