Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 10/8/2025

Isolated Limb Perfusion Safety Guidelines

Efficacy and Safety of Isolated Limb Perfusion

  • The American Society of Clinical Oncology recommends isolated limb perfusion (ILP) with controlled leakage (<1%) as a highly effective and safe procedure for melanoma, with complete response rates of 58% and low toxicity 1, 2
  • The National Comprehensive Cancer Network guidelines suggest that ILP should only be performed in centers with technical expertise to manage the procedure and potential complications, highlighting the importance of continuous leakage monitoring 3