Progesterone-Related Side Effects in Menopausal Hormone Therapy

Clinical Considerations

• Transdermal routes of hormone administration may cause fewer side effects than oral routes, particularly for symptoms related to fluid retention 1

Management Approaches

• The American College of Physicians recommends using the lowest effective dose of progesterone for the shortest possible time to minimize side effects, such as bloating and weight gain, in women on menopausal hormone replacement therapy 2, 1