Administering Glipizide for Optimal Glycemic Control

General Recommendations

• The American Diabetes Association, as reflected in guidelines from Diabetes Care, recommends that individuals who take insulin secretagogues like glipizide should prioritize coordinating the medication with food intake to achieve optimal glycemic control 1, 2
• Patients should never skip meals when taking sulfonylureas like glipizide, regardless of when the medication is taken, to reduce the risk of hypoglycemia 1, 5

Special Considerations for Fasting Patients

• For patients who fast, sulfonylureas like glipizide should be taken before the main meal of the day, according to Praxis Medical Insights 3
• For patients on once-daily dosing during fasting periods, the dose should be given before the sunset meal, as recommended by Diabetes Care 4, 3
• For patients on twice-daily dosing who are fasting, Diabetes Care recommends splitting the dose between meals 4