Potential Interactions Between Bupropion and Amphetamine/Dextroamphetamine

Key Interaction Concerns

The American College of Physicians recommends that concurrent use of bupropion and amphetamine/dextroamphetamine should be approached with caution due to the increased risk of seizures, which may be potentiated when combined, with a dose-dependent risk of seizures associated with bupropion 1, 2, 3

The American College of Physicians suggests that when used together, lower initial doses of both medications may be warranted, with careful titration essential to minimize adverse effects 2, 3
The American College of Obstetricians and Gynecologists recommends that bupropion SR typically starts at 100-150 mg daily, with maintenance dose of 100-150 mg twice daily, and careful monitoring for insomnia, which both medications can cause 1, 2, 4, 5, 6

The American College of Physicians notes that bupropion has been studied as an alternative to stimulants for ADHD treatment, showing efficacy comparable to methylphenidate in some studies, and has a significantly lower rate of sexual adverse events compared to many antidepressants 1, 2, 3

The American College of Obstetricians and Gynecologists states that limited data exists on the combination of bupropion and amphetamine/dextroamphetamine in pregnancy, though individual safety profiles have been studied, with possible associations with cardiovascular malformations and increased risks for NICU admission 4, 5, 6
The American Academy of Neurology recommends that this combination should generally be avoided in patients with a history of seizures 1, 2, 3