Benfotiamine's Role in Preventing AGE Accumulation

Clinical Evidence and Recommendations

The American Heart Association recommends prioritizing proven dietary strategies over supplementation, including consuming polyphenol-rich beverages like green tea (3+ cups daily) and coffee (3+ cups daily), which contain compounds that trap reactive dicarbonyl species and reduce AGE formation 1
Dietary modification focusing on water-based cooking methods (boiling, steaming), lower cooking temperatures, shorter cooking times, and avoiding high-heat methods (grilling, frying, roasting) significantly reduces dietary AGE intake 2, 3
Foods with high AGE content include ground-nuts, biscuits, cereals, toast, and high-heat-processed meats, while coffee, fruits, vegetables, butter, olive oil, and red wine have negligible AGE content 2

For patients concerned about AGE accumulation, consider benfotiamine supplementation (1,050 mg/day based on human studies) specifically for patients with diabetes who have evidence of microvascular or macrovascular complications 1