Urolithin A and Cardiovascular Health

Introduction to Urolithin A's Cardiovascular Effects

• Urolithin A modulates autophagy and has shown anti-aging properties, inducing mitophagy in cell cultures, increasing longevity in nematodes, and preventing age-related muscle impairment in mouse models 1, 2
• In healthy, sedentary elderly individuals, Urolithin A administration produces changes in muscle mitochondrial gene expression suggestive of improved mitochondrial and cellular health 1, 2

Clinical Considerations for Urolithin A Use

• For patients with established cardiovascular disease, Urolithin A should not replace guideline-directed medical therapy including antiplatelet agents, statins, ACE inhibitors, and revascularization when indicated 3