Bactrim for Gram-Positive Organisms

Efficacy and Resistance

The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines suggest that for certain resistant organisms, Bactrim may develop resistance during treatment, requiring monitoring of susceptibility patterns 1
For some gram-positive infections, particularly those caused by resistant strains, alternative agents may be preferred, as noted by the ESCMID guidelines 1
The ESCMID guidelines note that in certain serious infections, subsequent isolates may develop resistance to trimethoprim-sulfamethoxazole during treatment 1

Pregnant women should avoid Bactrim due to potential risks, as noted in sexually transmitted disease treatment guidelines from the Centers for Disease Control and Prevention (CDC) 2