Prednisone-Associated Constipation

Introduction to Prednisone Side Effects

• Constipation is listed as a potential side effect of prednisone, though it occurs less frequently than other gastrointestinal effects 1, 2
• Approximately 50% of patients experience short-term corticosteroid-related adverse events, with gastrointestinal effects including dyspepsia being common 3, 4
• The American Gastroenterological Association notes that other more frequently reported gastrointestinal side effects of prednisone include nausea, vomiting, and abdominal pain 1, 2
• Patients should be advised about possible constipation and other gastrointestinal side effects when starting prednisone therapy, as recommended by the American Gastroenterological Association 4, 5