Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/14/2025

Comprehensive Management of Multimorbidity

Identification and Assessment

  • The American College of Physicians recommends identifying patients with multimorbidity at risk of adverse events using prognostic models, either opportunistically during routine care or through systematic screening 1, 3
  • Patients with multiple conditions who take multiple medications face increased complexity in care management, according to the American Geriatrics Society 1, 2
  • The Mayo Clinic suggests considering patients with chronic multisymptom illness who may present with multiple poorly understood symptoms across different body systems 4

Patient-Centered Care

  • The American College of Physicians recommends eliciting patient preferences and expectations regarding their care, and engaging in shared decision-making with patients about treatment options and level of involvement 1, 2, 6
  • The Journal of Internal Medicine suggests discussing with patients the purpose of medication optimization to improve quality of life and function 5
  • Patients should be encouraged to express their personal values, aims, and priorities regarding treatment, according to the American Academy of Family Physicians 5

Treatment Optimization

  • The American College of Physicians recommends applying guiding principles that optimize treatment benefits over possible harms 1, 2, 6
  • The Mayo Clinic suggests considering cognitive-behavioral therapy and mindfulness-based treatments for patients with chronic multisymptom illness 4
  • Exercise should be considered for patients with symptoms consistent with fibromyalgia syndrome, according to the American College of Rheumatology 4

Care Planning and Communication

  • The Journal of Internal Medicine recommends developing care plans that address ongoing medical and social care needs while focusing on enhancing social connectedness and community involvement 7
  • An individualized patient-held medication plan should be used, including specific information on drugs and instructions for usage, according to the American Geriatrics Society 7
  • Ongoing and adequate communication is essential, particularly around medicines and wider care plans, as suggested by the American Academy of Family Physicians 7

Monitoring and Follow-up

  • The Journal of Internal Medicine recommends reviewing and updating medication/care plans regularly to recognize and record changes in needs 7
  • Regular follow-up appointments should be scheduled to assess medication effectiveness and adverse effects, according to the American College of Physicians 5
  • Treatment effects and clinical parameters, as well as side effects, should be monitored at follow-up appointments, as suggested by the American Academy of Family Physicians 7

Organizational Considerations

  • A multidisciplinary team approach should be implemented, especially involving clinical pharmacists when available, according to the American College of Clinical Pharmacy 5
  • Computerized decision support systems can support decision making and prescribing, but should not replace clinical judgment, as recommended by the American Medical Informatics Association 7
  • Regular self-assessment of the unit should be conducted to improve quality of care and service, according to the American College of Medical Quality 8