Management of Olanzapine-Associated Side Effects

Sexual Dysfunction Management

Counsel patients on risks of untreated asymptomatic hyperprolactinemia, including reduced bone mineral density and increased breast cancer risk in women, as 30% of adults develop high prolactin concentrations on olanzapine versus 10.5% on placebo 1

Chlorpromazine can be used to treat intractable hiccups while the patient continues olanzapine, but be cautious when using chlorpromazine concurrently with olanzapine to avoid excessive dopamine blockade 2
The combination of multiple antipsychotics, such as olanzapine and chlorpromazine, increases risk of QTc prolongation and other cardiac adverse effects, and consider cardiorespiratory monitoring and electrocardiogram monitoring 2
Be cautious when using chlorpromazine concurrently with olanzapine to avoid additive anticholinergic effects, such as constipation, dry mouth, and tachycardia, due to olanzapine's muscarinic receptor affinity 3