Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 11/11/2025

Invasive Positive Pressure Ventilation Parameters

Standard IPV/Mechanical Ventilation Parameters

  • The American Academy of Sleep Medicine recommends that Inspiratory Positive Airway Pressure (IPAP) should be set between 8 cm H₂O and 20-30 cm H₂O depending on age 1, 2
  • The American Academy of Sleep Medicine suggests that Expiratory Positive Airway Pressure (EPAP) should be set starting at 4 cm H₂O 2
  • The American Academy of Sleep Medicine recommends that Pressure Support (PS) should be set between 4 cm H₂O and 20 cm H₂O 2, 3
  • The American Academy of Sleep Medicine recommends that Respiratory Rate/Backup Rate should be set equal to or slightly less than spontaneous sleeping respiratory rate with a minimum of 10 bpm 1, 3
  • The American Academy of Sleep Medicine suggests that Inspiratory Time (IPAP time) should be set between 30-40% of cycle time (60/respiratory rate), typically around 1.2 seconds 3, 4

Clinical Application for Standard Mechanical Ventilation

  • For pressure support ventilation in prolonged invasive ventilation, the American Academy of Sleep Medicine recommends that pressure support should be increased every 5 minutes if tidal volume is low (<6-8 mL/kg) 1, 3

REFERENCES

1

best clinical practices for the sleep center adjustment of noninvasive positive pressure ventilation (nppv) in stable chronic alveolar hypoventilation syndromes. [LINK]

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2010

2

best clinical practices for the sleep center adjustment of noninvasive positive pressure ventilation (nppv) in stable chronic alveolar hypoventilation syndromes. [LINK]

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2010

3

best clinical practices for the sleep center adjustment of noninvasive positive pressure ventilation (nppv) in stable chronic alveolar hypoventilation syndromes. [LINK]

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2010

4

best clinical practices for the sleep center adjustment of noninvasive positive pressure ventilation (nppv) in stable chronic alveolar hypoventilation syndromes. [LINK]

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2010