Treatment of Hypoferritinemia

Treatment Algorithm

• The American Society of Hematology recommends continuing oral iron treatment for 8-10 weeks and monitoring response with repeat ferritin and hemoglobin measurements after 8-10 weeks, with a target ferritin level of ≥50 μg/L in the absence of inflammation 1
• Dietary modifications, such as avoiding iron absorption inhibitors like tea, coffee, and calcium, and limiting alcohol intake, especially with elevated liver enzymes, can help improve iron absorption 2, 3
• The American Society of Hematology suggests considering intravenous iron in cases of malabsorption disorders, need for rapid repletion, and failure of oral therapy, with options including iron dextran, ferric carboxymaltose, and ferric derisomaltose 1
• It is recommended to avoid measuring iron parameters within 4 weeks of intravenous iron administration as it can interfere with test results 1