Sitagliptin Safety During Breastfeeding

General Considerations

Most medications taken by breastfeeding mothers are compatible with breastfeeding, with only a limited number of agents contraindicated, according to the American Academy of Pediatrics 1

Breastfeeding is recommended for all individuals with diabetes, including those with a history of gestational diabetes mellitus (GDM), as stated by the American Diabetes Association 2
Insulin sensitivity increases dramatically in the postpartum period, with insulin requirements approximately 34% lower than pre-pregnancy levels immediately after delivery, as reported by the American Diabetes Association 2
Breastfeeding may increase the risk of overnight hypoglycemia in mothers with diabetes, and insulin dosing may need adjustment, according to the American Diabetes Association 2

The Drugs and Lactation Database (LactMed) is the most comprehensive source for medication safety during breastfeeding and should be consulted for the most current information, as recommended by the American Academy of Pediatrics 1
As with any medication during breastfeeding, monitor the infant for unusual symptoms or changes in feeding patterns, according to the American Academy of Pediatrics 1
The benefits of maintaining good glycemic control in the mother generally outweigh the theoretical risks of medication exposure through breast milk, as stated by the American Diabetes Association 2