Initiation of Paliperidone Palmitate LAI

Evidence-Based Initiation Protocol

• The American Psychiatric Association guidelines historically recommended using the oral form of the same medication as the logical choice for initial treatment before LAI initiation, but this is not required for paliperidone palmitate LAI 1

Contrast with Other Long-Acting Injectables

• The unique nanocrystal formulation and loading dose regimen of paliperidone palmitate obviate the requirement for oral tolerance testing, as stated by guidelines from societies such as the American Psychiatric Association, although the exact statement is from the British Journal of Psychiatry 1