Statin‑First Strategy for Primary Prevention in Adults with Moderate‑to‑Severe Hypertriglyceridemia

ASCVD Risk Assessment and Indications for Statin Therapy

Rationale for Prioritising Statins Over Fenofibrate

Practical Management Algorithm

Initiation of High‑Intensity Statin

Lifestyle Modification (Concurrent)

Reassessment and Escalation

When Fenofibrate Becomes First‑Line

Expected Lipid Outcomes with Statin‑First Strategy

All bullet points are derived from ACC/AHA guideline statements and supported by the cited references.