Nausea Treatment with Droperidol and Haloperidol

Evidence for Droperidol as an Antiemetic

• The American College of Emergency Physicians suggests that droperidol can be used for nausea treatment, with evidence from studies showing its efficacy in postoperative and acute care settings 1, 2, 3

Safety Considerations

• The American Heart Association recommends avoiding droperidol in patients with known QTc prolongation >500 ms or significant cardiac disease, due to the risk of QTc interval prolongation 5
• Haloperidol causes approximately 7 ms QTc prolongation, although the clinical significance remains debatable 5

Clinical Algorithm for Nausea Treatment

• For patients with nausea without contraindications, the American College of Emergency Physicians recommends assessing response to droperidol at 30 minutes 3