Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 6/13/2025

Apnea of Prematurity Treatment

Introduction to Caffeine Citrate

  • Caffeine citrate improves pulmonary function in infants with chronic lung disease, according to the American Thoracic Society, by facilitating weaning from mechanical ventilation and potentially reducing the need for intubation 1

Respiratory Support and Benefits

  • The use of caffeine citrate in premature infants (28-32 weeks gestational age) is supported by evidence, although the specific citation for this fact is not provided, it is implied to be effective in this population
  • Improves survival outcomes and reduces the risk of bronchopulmonary dysplasia, however the specific citation for this is not provided

Dosage and Administration

Safety and Monitoring

Efficacy and Comparison

REFERENCES

1

statement on the care of the child with chronic lung disease of infancy and childhood. [LINK]

American Journal of Respiratory and Critical Care Medicine, 2003